TurboGears

Yet another Python-based web framework, TurboGear uses the MVC pattern that starts as a microframework and can quickly scale up to a full-stack solution. In other words, you can use it through a minimal mode that can highly simplify your tasks in simpler projects but you can change it to a more complete mode at any time to meet increasing requirements. 

TurboGears is a Python web application framework consisting of several WSGI components such as WebOb, SQLAlchemy, Genshi and Repoze. TurboGears is designed around the model–view–controller (MVC) architecture, much like Struts or Ruby on Rails, designed to make rapid web application development in Python easier and more maintainable.